Immobilized IL-2 Protein, Mouse (Cat. No. UA040171) at 2 μg/mL (100 μL/well) can bind Mouse IL-2R alpha/CD25 Protein, His tag with EC50 of 10.5-15.3 ng/ml.
Mouse Soluble IL2R alpha/CD25 Protein, His Tag
Mouse Soluble IL2R alpha/CD25 Protein, His Tag
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, p55, CD25, Il2ra, Il2r |
| Accession | P01590 |
| Amino Acid Sequence | Protein sequence (P01590, Glu22-Lys236, with C-His Tag) ELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYK |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 26.4 kDa Observed MW: 45-70 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). This receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis. Quantification of soluble IL2RA is a useful and simple tool for clinicians to assess immune function in vivo as part of the investigation, management, and prognosis of a broad spectrum of diseases, such as sarcoidosis, Multiple Sclerosis, primary biliary cirrhosis, Chronic immune activation in common variable immunodeficiency (CVID), chronic liver diseases and many more.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
