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Mouse SLAMF8 Protein, His Tag

Mouse SLAMF8 Protein, His Tag

Catalog Number: S0A1157 Brand: Starter
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$70 USD
$70 USD
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Product Details

Product Specification


Species Mouse
Synonyms SLAM family member 8, B-lymphocyte activator macrophage expressed, CD353, Blame
Accession Q9D3G2
Amino Acid Sequence

Protein sequence (Q9D3G2, Val21-Asp231, with C-His Tag) VQVLSKVGDSELLVAECPPGFQVREAIWRSLWPSEELLATFFRGSLETLYHSRFLGRVQLYDNLSLELGPLKPGDSGNFSVLMVDTGGQTWTQTLYLKVYDAVPKPEVQVFTAAAEETQPLNTCQVFLSCWAPNISDITYSWRWEGTVDFNGEVRSHFSNGQVLSVSLGLGDKDVAFTCIASNPVSWDMTTVTPWESCHHEAASGKASYKD
Expression System HEK293
Molecular Weight Predicted MW: 25.1 kDaObserved MW: 30-40 kDa
Purity ＞90% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
Reconstitution Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

SLAMF8 (SLAM Family Member 8), also known as BLAME (B-lymphocyte activator macrophage expressed), is a cell surface receptor belonging to the signaling lymphocyte activation molecule (SLAM) family. Primarily expressed on myeloid cells such as macrophages and dendritic cells, it plays a crucial role in immune regulation. Unlike other SLAM family members, SLAMF8 acts as a negative regulator of inflammatory responses. Research indicates its involvement in macrophage polarization, phagocytosis, and the maintenance of immune homeostasis. It is also implicated in the pathogenesis of inflammatory bowel disease and the tumor microenvironment, making it a potential biomarker for immune-related disorders.

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SDS-PAGE

2μg（R: reducing conditions）