Mouse IL-6 Recombinant mAb (SDT-1630-38)
Mouse IL-6 Recombinant mAb (SDT-1630-38)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Mouse IL-6 |
| Synonyms | Interleukin-6; B-cell hybridoma growth factor; Interleukin HP-1; Il6 |
| Location | Secreted |
| Accession | P08505 |
| Clone Number | SDT-1630-38 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Ms |
| Cross Reactivity | No cross-reactivity against Mouse LIF, IL-6R alpha/CD126, OSM protein. |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Mouse IL-6, also known as interleukin-6, is a multifunctional cytokine that plays a crucial role in the immune response, hematopoiesis, inflammation, and the acute phase response. It is primarily produced by T cells, macrophages, monocytes, endothelial cells, and muscle cells. IL-6 binds to the IL-6 receptor (IL-6R) and triggers the association of IL-6R with gp130, leading to signal transduction through JAKs and STATs. This cytokine stimulates B cell differentiation and antibody production, supports the growth of myeloma and plasmacytoma, and aids in nerve cell differentiation. Additionally, IL-6 acts as a myokine, produced by muscle cells in response to muscle contraction, and helps in breaking down fats and improving insulin resistance. In mice, IL-6 is also a dominant endocrine cytokine induced by acute stress, playing a role in stress hyperglycemia and the "fight or flight" response.
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