Mouse IL-17A Single Plex Kit (Flow Cytometry Bead Assay)

Mouse IL-17A (also known as CTLA-8) is a pro-inflammatory cytokine and the signature effector molecule of Th17 cells, with additional sources including γδ T cells, iNKT cells, and type 3 innate lymphoid cells (ILC3). Functioning as a master regulator of mucosal immunity, IL-17A signals through the IL17RA–IL17RC heterodimeric receptor complex to activate NFκB and MAPK pathways, thereby inducing the production of proinflammatory cytokines (such as TNFα and IL6), chemokines (including CXCL1 and CXCL5), antimicrobial peptides, and matrix metalloproteinases. This signaling cascade orchestrates neutrophil recruitment and activation, positioning IL17A as a critical mediator of host defense against extracellular bacteria and fungi. However, dysregulated IL17A expression is pathologically linked to a broad spectrum of autoimmune and inflammatory diseases, including rheumatoid arthritis, psoriasis, and multiple sclerosis, and has also been implicated in airway hyperresponsiveness, inflammatory bone loss, and even neurodevelopmental disorders such as autism spectrum disorder. In the context of cancer, IL17A exhibits a controversial dual role, with reports indicating both tumorsuppressive and tumorpromoting activities depending on the microenvironment. Given its central role in bridging adaptive and innate immunity, quantitative detection of mouse IL17A serves as an invaluable tool for studying Th17 differentiation, autoimmunity, host defense mechanisms, and the inflammatory tumor microenvironment, making it a key biomarker for evaluating immune status and inflammatory pathology in diverse research models.