mouse IL-12 p70 Recombinant mAb (SDT-1778-99)
mouse IL-12 p70 Recombinant mAb (SDT-1778-99)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-12 p70 |
| Synonyms | Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit (CLMF p35); IL-12 subunit p35; Il12a; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40); IL-12 subunit p40 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | P43431、P43432 |
| Clone Number | SDT-1778-99 |
| Application | Sandwich ELISA |
| Reactivity | Ms |
| Cross Reactivity | No cross-reactivity against human il-12, mouse il-2, mouse il-4, mouse il-6, mouse il-7, mouse il-10 and mouse TNF alpha |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Interleukin-12 p70 (IL-12 p70) is a disulfide-linked heterodimeric cytokine composed of a 35-kDa light chain (p35) and a 40-kDa heavy chain (p40), functioning as the biologically active form of IL-12 secreted primarily by antigen-presenting cells such as dendritic cells, macrophages, and B cells upon recognition of pathogens; it drives the differentiation of naïve CD4+ T cells toward the Th1 phenotype, synergizes with IL-18 to induce large amounts of IFN-γ from T and NK cells, bridges innate and adaptive immunity, and is implicated in protective immunity against intracellular bacteria, viruses, and tumors, yet its dysregulation contributes to autoimmune and inflammatory disorders.
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