2μg (R: reducing conditions)
Mouse CAIX , His tag
Mouse CAIX , His tag
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX), Membrane antigen MN homolog, Ca9, Car9 |
| Accession | Q8VHB5 |
| Amino Acid Sequence | Protein sequence(Q8VHB5, Ser118-Asp390, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:31.6kDa Actual:34kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Carbonic anhydrase IX (CA9/CAIX) is one of the 14 carbonic anhydrase isoforms found in humans and is a transmembrane dimeric metalloenzyme with an extracellular active site that facilitates acid secretion in the gastrointestinal tract. CAIX is overexpressed in many types of cancer including clear cell renal cell carcinoma (RCC) as well as carcinomas of the cervix, breast and lung where it promotes tumor growth by enhancing tumor acidosis.
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