Mouse Anti-Mouse RORγt Antibody (S-4440)

RORγt (Retinoic Acid Receptor-Related Orphan Nuclear Receptor-γt) is a critical transcription factor in the immune system, predominantly expressed in immune cells such as Th17 cells, γδT cells, and type 3 innate lymphoid cells (ILC3s), where it serves as the "master regulator" driving the production of the pro-inflammatory cytokine IL-17. Its function is multifaceted: under normal physiological conditions, it is essential for the development of secondary lymphoid organs (e.g., lymph nodes, Peyer's patches) and the maintenance of intestinal immune homeostasis; however, its aberrant function or hyperactivation drives the pathological processes of various autoimmune and chronic inflammatory diseases (such as psoriasis, rheumatoid arthritis, multiple sclerosis, etc.). Consequently, the development of small-molecule drugs targeting its ligand-binding domain (LBD) has become a prominent focus in the treatment of these conditions, yet it also faces the challenge of suppressing its pathogenic inflammatory functions without compromising its normal immunoregulatory roles.