Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD244.2 antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD49b - FITC Antibody separately.
Mouse Anti-Mouse CD244.2 Antibody (S-R736)
Mouse Anti-Mouse CD244.2 Antibody (S-R736)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD244.2 |
| Synonyms | Natural killer cell receptor 2B4; NK cell type I receptor protein 2B4 (NKR2B4); Non-MHC restricted killing associated; SLAM family member 4 (SLAMF4); Signaling lymphocytic activation molecule 4; 2b4; Nmrk; Cd244 |
| Location | Cell membrane |
| Accession | Q07763 |
| Clone Number | S-R736 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD244.2 protein, also known as natural killer cell receptor 2B4 isoform 2 precursor, is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family. It is encoded by the CD244 gene and primarily expressed in various immune cells such as NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. This protein mainly binds to its ligand CD48, another SLAM family member, to transmit stimulatory or inhibitory signals and regulate immune responses, including NK cell-mediated cytotoxicity, leukocyte activation, and cytokine production. CD244.2 plays a crucial role in the immune system and has potential as a therapeutic target in cancer and other immune-related diseases.
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