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Mouse Anti-Human TIM-3 Antibody (S-R642)

Mouse Anti-Human TIM-3 Antibody (S-R642)

Catalog Number: S0B8460 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter
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Product Details

Product Specification


Host Mouse
Antigen TIM-3
Synonyms Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3); T-cell immunoglobulin mucin receptor 3 (TIM-3); T-cell membrane protein 3; CD366; TIM3; TIMD3; HAVCR2
Location Cell membrane, Cell junction
Accession Q8TDQ0
Clone Number S-R642
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:2000 Hu

Background

TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) is a transmembrane checkpoint receptor selectively expressed on interferon-γ-producing T cells, Tregs, and innate immune cells; engagement of its ligands (galectin-9, CEACAM1, HMGB1, phosphatidylserine) triggers inhibitory signaling that terminates Th1 responses, promotes T-cell exhaustion, and fosters tolerogenic dendritic cell activity, thereby serving as a key negative regulator of antitumor and antimicrobial immunity and representing an actionable target for cancer immunotherapy.

Picture

FC

Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human TIM-3 antibody at 1/2000 dilution (0.1 μg) / (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD56 - APC Antibody separately.