Flow cytometric analysis of 50ng/ml PMA, 1μg/ml Ionomycin and 1μg/ml BFA cultured human PBMC (human peripheral blood mononuclear cell) labelling human IL-9 antibody at 1/2000 dilution (0.1 μg) / (Right Panel) compared with a Mouse IgG2b, κ Isotype control (Left Panel). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD3 - Alexa Fluor® 488 separately. Gated on total viable cells.
Mouse Anti-Human IL-9 Antibody (S-2920)
Mouse Anti-Human IL-9 Antibody (S-2920)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | IL-9 |
| Synonyms | Interleukin-9; Cytokine P40; T-cell growth factor P40; IL9 |
| Location | Secreted |
| Accession | P15248 |
| Clone Number | S-2920 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:2000 | Hu |
Background
Interleukin-9 (IL-9) is a 14 kDa glycoprotein cytokine primarily produced by activated Th2, Th9, and innate lymphoid cells that signals through a heterodimeric receptor composed of the IL-9Rα chain and the common γ-chain, thereby activating JAK/STAT, PI3K/AKT, and MAPK pathways to exert pleiotropic effects on hematopoietic and epithelial cells, promoting mast-cell proliferation and differentiation, enhancing mucus production by goblet cells, modulating B-cell responses, and contributing to the pathogenesis of allergic asthma, atopic dermatitis, and certain hematologic malignancies, while also exerting context-dependent anti-tumor or pro-tumor activities depending on the cellular milieu.
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