Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human GPR15 antibody at 1/100 dilution (2 μg) / (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (Left panel). Followed by Anti-Mouse IgG (H+L) biotin and Sav-PE. Then cells were stained with CD4 - Brilliant Violet 421™ Antibody separately.
Mouse Anti-Human GPR15 Antibody (S-3534)
Mouse Anti-Human GPR15 Antibody (S-3534)
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Product Details
Product Details
Product Specification
| Synonyms | G-protein coupled receptor 15; Brother of Bonzo (BoB) |
| Location | Cell membrane |
| Accession | P49685 |
| Clone Number | S-3534 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:100 | Hu |
Background
GPR15 is a class-A orphan G-protein-coupled receptor best known for guiding colon-specific homing of T cells, especially FOXP3+ Tregs and effector subsets, via its recently identified ligand C10orf99 (GPR15L), a 9 kDa chemokine-like peptide abundant in gut epithelia; beyond establishing intestinal immune homeitasis, GPR15 also serves as an HIV/SIV co-receptor, is up-regulated by TGF-β and the aryl hydrocarbon receptor, exhibits species-specific expression patterns, and has emerged as a potential therapeutic target for colitis and other mucosal inflammatory disorders.
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