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Mouse Anti-Human CD8α Antibody (S-3972)

Mouse Anti-Human CD8α Antibody (S-3972)

Catalog Number: S0B8453 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter
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Product Details

Product Specification


Host Mouse
Antigen CD8α
Synonyms T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A
Location Secreted, Cell membrane
Accession P01732
Clone Number S-3972
Antibody Type Mouse mAb
Isotype IgG2a
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:2000 Hu

Background

CD8α is a crucial immune glycoprotein that plays a vital role in the immune response by serving as a co-receptor for the T-cell receptor (TCR) on cytotoxic T cells. It forms either a homodimer (α/α) or a heterodimer with CD8β (α/β) to interact with MHC class I molecules on antigen-presenting cells (APCs), facilitating the recognition of intracellular pathogens such as viruses. CD8α also recruits the LCK kinase, which initiates downstream signaling pathways essential for T-cell activation and proliferation. This molecule is critical for the function of cytotoxic T lymphocytes (CTLs) and is involved in various immune-related diseases, including immunodeficiencies and autoimmune conditions.

Picture

FC

Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human CD8α antibody at 1/2000 dilution (0.1 μg) / (Right panel) compared with a Mouse IgG2a Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD4 – FITC Antibody (S0B1537) separately.