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Mouse Anti-Human CD73 Antibody (AD2)

Mouse Anti-Human CD73 Antibody (AD2)

Catalog Number: S0B60386 Application: FCM Reactivity: Hu Conjugation: Unconjugated Brand: Starter
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$100 USD
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Product Details

Product Specification


Host Mouse
Antigen CD73
Synonyms 5'-nucleotidase; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase; NT5; NTE; NT5E
Location Cell membrane
Accession P21589
Clone Number AD2
Antibody Type Mouse mAb
Isotype IgG1,k
Isotype Control S0B0617
Application FCM
Reactivity Hu
Positive Sample Human peripheral blood lymphocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CD73, also known as ecto-5'-nucleotidase (encoded by NT5E), is a glycosylphosphatidylinositol (GPI)-anchored cell-surface enzyme that catalyzes the final step of extracellular ATP degradation, converting AMP to immunosuppressive adenosine, thereby orchestrating tumor immune evasion, promoting angiogenesis and metastasis, and shaping an anti-inflammatory microenvironment by dampening CD8⁺ T-cell cytotoxicity and enhancing Treg or myeloid suppressive functions across multiple solid cancers.

Picture

FC

Flow cytometric analysis of human peripheral blood lymphocytes labeled with anti-Human CD73 antibody at 1/200 dilution (1 μg) / (right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti- Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ Antibody separately. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.