Flow cytometric analysis of human peripheral blood leukocytes labelling CD66a/c/e antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG2b, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody.
Mouse Anti-Human CD66a/c/e Antibody (S-3923)
Mouse Anti-Human CD66a/c/e Antibody (S-3923)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD66a/c/e |
| Synonyms | CEACAM1; BGP-1; BGP; BGP1; CEACAM6; NCA; CEACAM5; CEA |
| Location | Cell membrane |
| Accession | P13688、P40199、P06731 |
| Clone Number | S-3923 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocytes |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD66a/c/e are closely related glycoproteins of the carcinoembryonic-antigen family that share an N-terminal IgV-like domain followed by up to three IgC2-like domains, differ mainly in membrane anchorage (CD66a is transmembrane whereas CD66c and CD66e are GPI-linked), and collectively mediate calcium-independent homophilic and heterophilic adhesion, pathogen recognition (e.g., gonococcal Opa proteins bind peptide determinants in their N-domains), neutrophil activation, and modulation of innate and adaptive immunity, apoptosis, angiogenesis, and tumor behavior.
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