Flow cytometric analysis of human peripheral blood leukocytes labelling Human CD192 antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 421™ Antibody separately.
Mouse Anti-Human CD192 Antibody (S-2971)
Mouse Anti-Human CD192 Antibody (S-2971)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD192 |
| Synonyms | C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; CCR2; Monocyte chemoattractant protein 1 receptor (MCP-1-R); CMKBR2 |
| Location | Cell membrane |
| Accession | P41597 |
| Clone Number | S-2971 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood leukocytes |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD192, also called CCR2, is a 42 kDa seven-transmembrane G-protein-coupled receptor expressed mainly on monocytes, macrophages and basophils that binds the chemokines MCP-1 (CCL2), MCP-3 (CCL7) and MCP-4 (CCL13), triggers intracellular calcium flux and inhibition of adenylyl cyclase, thereby directing chemotaxis and bone marrow homeostasis, and has been implicated in inflammatory diseases such as rheumatoid arthritis, atherosclerosis and cancer as well as serving as an alternative HIV-1 coreceptor with CD4.
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