Flow cytometric analysis of Raji (Human Burkitt's lymphoma B lymphocyte, left) / U-937 (Human histiocytic lymphoma monocyte, right) labeled with CD155 antibody at 1/200 dilution (1 μg) / (red) compared with a Mouse IgG2b, k (black) Isotype Control. Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Negative control: Raji
Mouse Anti-Human CD155/PVR Antibody (SKII.4)
Mouse Anti-Human CD155/PVR Antibody (SKII.4)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD155/PVR |
| Synonyms | Poliovirus receptor; Nectin-like protein 5 (NECL-5); PVS |
| Location | Cell membrane |
| Accession | P15151 |
| Clone Number | SKII.4 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B0617 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | U-937 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD155, also designated PVR (poliovirus receptor) and Necl-5, is a ~70 kDa primate-restricted type I transmembrane glycoprotein of the immunoglobulin superfamily that contains one V-type and two C2-type extracellular Ig-like domains, a 24-aa transmembrane segment and a 50-aa cytoplasmic tail; it serves as the cellular entry receptor for poliovirus, mediates cell adhesion by binding vitronectin and nectin-3, and engages immune receptors DNAM-1/CD226, CD96 and TIGIT to regulate NK-cell cytotoxicity, T-cell activation and tumor-cell recognition, while its expression—up-regulated by IFN-γ on endothelial cells and abundant on immature thymocytes, dendritic cells and epithelial/neuronal tumor cells—promotes cell migration, loss of contact inhibition and transendothelial migration.
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