Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cell) labelling CD127 antibody at 1/2000 (0.1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ separately. Gated on total viable cells.
Mouse Anti-Human CD127 Antibody (S-R462)
Mouse Anti-Human CD127 Antibody (S-R462)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD127 |
| Synonyms | Interleukin-7 receptor subunit alpha, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, CDw127 |
| Location | Cell membrane |
| Accession | P16871 |
| Clone Number | S-R462 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | null |
Background
CD127, also known as the interleukin-7 receptor alpha chain (IL-7Rα) or simply the IL-7 receptor, is a transmembrane glycoprotein primarily expressed on the surface of T cells, B cells, natural killer (NK) cells, as well as certain hematopoietic stem cells and progenitor cells. Upon binding to IL-7, CD127 activates a series of signaling pathways, including the JAK-STAT cascade, which subsequently promotes the growth and differentiation of lymphocytes. This interaction is particularly crucial during the development of T and B cells within the thymus and bone marrow, as it aids in their progression from early progenitor stages to maturity. Furthermore, the expression level of CD127 serves as an indicator for assessing lymphocyte function and status.
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