Mouse Anti-Human CD125 Antibody (S-4480)

CD125, also known as the interleukin-4 receptor subunit alpha (IL-4Rα), is a type I transmembrane protein that serves as a critical shared signaling component for both the type I and type II interleukin-4 receptors, thereby playing a pivotal role in regulating immune responses, particularly those associated with Th2-mediated inflammation, allergic reactions, and asthma. As the primary binding subunit for interleukin-4 (IL-4) and interleukin-13 (IL-13), CD125 facilitates the activation of downstream signaling pathways, most notably the JAK-STAT pathway (specifically JAK1/STAT6), which leads to the transcription of genes involved in IgE class switching, eosinophil recruitment, mucus production, and alternative macrophage activation. Structurally, it consists of an extracellular domain responsible for cytokine binding, a single transmembrane helix, and a cytoplasmic tail containing specific motifs that recruit Janus kinases, making it a significant therapeutic target; indeed, monoclonal antibodies such as dupilumab specifically inhibit the interaction of IL-4 and IL-13 with CD125 to effectively treat moderate-to-severe atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps by blocking this central axis of type 2 inflammatory signaling.