Flow cytometric analysis of human peripheral blood Leukocytes labelling Human CD11/CD18 antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody.
Mouse Anti-Human CD11/CD18 Antibody (S-2969)
Mouse Anti-Human CD11/CD18 Antibody (S-2969)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD18 |
| Synonyms | Integrin beta-2; MFI7; ITGB2; Integrin alpha-L; CD11a; ITGAL; CD11A; Integrin alpha-M; CR-3 alpha chain; CD11b; ITGAM; CD11B; CR3A; Integrin alpha-X; Leu M5; CD11c; ITGAX; CD11C |
| Location | Cell membrane |
| Accession | P05107、P20701、P11215、P20702 |
| Clone Number | S-2969 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood Leukocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD18, also known as integrin β2, is a 95 kDa glycoprotein that is a crucial component of several β2 integrins. These integrins are heterodimeric type I transmembrane proteins composed of a variable alpha chain (CD11a-d) and the common beta chain CD18. The CD18 protein is encoded by the ITGB2 gene in humans. It plays a significant role in cellular adhesion and immune responses. When CD18 binds with different alpha chains, it forms various heterodimers such as lymphocyte function-associated antigen-1 (LFA-1) with CD11a, and Macrophage-1 antigen receptor (Mac-1) with CD11b. These heterodimers are involved in processes like leukocyte adhesion to endothelial cells, phagocytosis, and immune cell activation. Deficiencies in CD18 expression can lead to adhesion defects in white blood cells, impairing the immune system's ability to fight infections.
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