Flow cytometric analysis of Foxp3 / Transcription Factor Staining Buffer Set fixed and permeabilized Human PBMC (human peripheral blood mononuclear cells) labelling Human Aiolos antibody at 1/200 dilution (1 μg) / (Right panel) compared with a Mouse IgG1, κ (Left panel) isotype control. Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ antibody separately.
Mouse Anti-Human Aiolos Antibody (S-3264)
Mouse Anti-Human Aiolos Antibody (S-3264)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | Aiolos |
| Location | Cytoplasm, Nucleus |
| Accession | Q9UKT9 |
| Clone Number | S-3264 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:200 | Hu |
Background
Aiolos (encoded by IKZF3) is a zinc-finger transcription factor of the Ikaros family that is indispensable for lymphocyte biology. By recruiting chromatin-remodeling complexes to its target genes, it enforces quiescence in mature B cells, orchestrates immunoglobulin receptor editing, and cooperates with other Ikaros members to direct late-stage B-cell maturation. Its deletion or inactivating mutations unleash malignant transcriptional programs, making Aiolos a key tumor suppressor whose loss underpins B-cell acute lymphoblastic leukemia and multiple myeloma.
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