Monkey GM-CSF Single Plex Assay (适用于Luminex)

Monkey granulocyte-macrophage colony-stimulating factor (GM-CSF) is a crucial cytokine that regulates the production, differentiation, and function of granulocytes and macrophages from hematopoietic progenitor cells. It is secreted by various cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, in response to immune or inflammatory stimuli. The biologically active form of the protein exists extracellularly as a homodimer. Recombinant monkey GM-CSF, derived from species like cynomolgus or rhesus macaques, is typically a non-glycosylated polypeptide chain consisting of approximately 127 amino acids with a molecular weight of about 14.4 kDa. It is commonly produced in expression systems such as E. coli or yeast for research applications. The biological activity of these recombinant proteins is often confirmed by their ability to stimulate the proliferation of human TF-1 cells, with an ED50 typically less than 0.1 ng/mL. Due to its essential role in myelopoiesis and immune modulation, monkey GM-CSF serves as a valuable tool for studying hematopoietic development and inflammatory responses in non-human primate models.