MOG His Tag Protein, Mouse
MOG His Tag Protein, Mouse
Product Details
Product Details
Product Specification
| Species | Mouse |
| Antigen | MOG |
| Synonyms | BTN6,BTNL11,MOGIG2,NRCLP7,Myelin oligodendrocyte glycoprotein |
| Accession | Q61885 |
| Amino Acid Sequence | Gly29-Gly153,with C-terminal 8*His |
| Expression System | HEK293 |
| Molecular Weight | 19-22kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Reindl, M. et al. (2013) Nat. Rev.Neurol. 9:455. |
Background
Myelinoligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging toimmunoglobulin superfamily. Mouse MOG issynthesized with a 28 amino acid (aa) signal sequence, a 128 aa extracellulardomain (ECD) containing an Ig-like domain, a 21 aa transmembrane domain, and a69 aa cytosolic fragment featuring a hydrophobic domain that associates withthe cytoplasmic face of the plasma membrane. MOG is expressed exclusively byoligodendrocytes in the central nervous system (CNS) and is localized to the outerlayer of the myelin sheath as well as in the oligodendrocyte plasma membrane.This makes MOG a potential target of cellular and humoral immune responses ininflammatory demyelinating diseases.
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SDS-PAGE
ELISA
Immobilized MOG His Tag Protein, Mouse (Cat. No. UA010433) at 2.0μg/mL (100μL/well) can bind Myelin Oligodendrocyte Glycoprotein (MOG) Recombinant Rabbit mAb (S-1384-61) (Cat. No. S0B0812) with EC50 of 0.92-1.16ng/mL.
