MMP3 Recombinant Rabbit mAb (SDT-1237-31)
MMP3 Recombinant Rabbit mAb (SDT-1237-31)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Matrix metalloproteinase-3 (MMP-3) |
| Synonyms | Stromelysin-1, Transin-1 |
| Immunogen | Recombinant Protein |
| Accession | P08254 |
| Clone Number | SDT-1237-31 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize TIMP-1, MMP-8, MMP-9 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Matrix metallopeptidase 3 (MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. As a secreted zinc-dependent endopeptidase, MMP3 exerts its functions mainly in the extracellular matrix. MMP-3 plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide information about progression of rheumatoid diseases, and potentially response to treatment.
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