1μg (R: reducing condition, N: non-reducing condition).
MMP-2 His Tag Protein, Mouse
MMP-2 His Tag Protein, Mouse
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$176.00 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | EC:3.4.24.24，Matrix Metallopeptidase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，MMP-2，MMP2，Matrix metalloproteinase-2，72 kDa gelatinase，Matrix Metallopeptidase 2，CLG4A，TBE-1，Matrix Metalloproteinase 2 (Gelatinase A， 72kDa Gelatinase， 72kDa Type IV Collagenase)，Matrix Metalloproteinase 2，Matrix Metalloproteinase-II，72 KDa Type IV Collagenase，Collagenase Type IV-A，Neutrophil Gelatinase，Gelatinase A，EC 3.4.24.24，MMP-II，MONA，CLG4，EC 3.4.24 |
| Accession | P33434 |
| Amino Acid Sequence | Met409-Cys662 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 33-43kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4,5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Thompson EW, et al. (1994) Collagen induced MMP-2 activation in human breast cancer. Breast Cancer Res Treat. 31(2-3): 357-70. |
Background
Matrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades extracellular matrix components, playing a pivotal role in cell migration during physiological and pathological processes. Its expression is regulated by EMMPRIN, Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation requires MT1-MMP and TIMP-2. Low MMP-2 levels are associated with a favorable prognosis in hormone receptor-negative tumors, which are typically high-risk. As a zymogen requiring proteolytic activation, MMP-2 is broadly implicated in cancer invasion and metastasis, including human breast cancer. Blocking MMP-2 secretion and activation during breast carcinoma development may reduce metastasis. The detection of active MMP-2 or the ratio of pro-MMP-2 to active MMP-2 is a highly sensitive indicator of cancer metastasis. Modulating MMP-2 expression and activation via specific inhibitors or activators offers a promising therapeutic strategy for breast cancer treatment.
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SDS-PAGE
SEC-HPLC
The purity of MMP-2 His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.
