2μg (R: reducing condition, N: non-reducing condition).
MARCO His Tag(79-520) Protein, Human
MARCO His Tag(79-520) Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2 |
| Accession | Q9UEW3 |
| Amino Acid Sequence | Met79-Val520, with N-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 60-75kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE, >95% by RP-HPLC & >90% by SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Kriemler L, Rudin S, Gawinecka J, Gross F, Arnold M, Schweizer J, Westphal L, Inauen C, Pokorny T, Dittrich T, Toebak A, Arnold M, Christ-Crain M, von Eckardstein A, Rentsch K, Katan M, De Marchis GM. Discordance between LDL-C and apolipoprotein B is associated with large-artery-atherosclerosis ischemic stroke in patients ⩽70 years of age. Eur Stroke J. 2024 Jan 26:23969873231221619. 2. Furlani F, Pota G, Rossi A, Luciani G, Campodoni E, Mocerino F, D'Errico G, Pezzella A, Panseri S, Vitiello G, Sandri M. Designing bioinspired multifunctional nanoplatforms to support wound healing and skin regeneration: Mg-hydroxyapatite meets melanins. Colloids Surf B Biointerfaces. 2024 Jan 15;235:113756. |
Background
MARCO (macrophage receptor with collagenous structure), also known as SCARA2, is an 80 kDa type II transmembrane glycoprotein that belongs to the class A scavenger receptor family. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. Its expression is induced on Kupffer cells and alveolar macrophages by microbial infection, chemical irritants, and Th1 polarizing factors. MARCO binds LPS, lipoteichoic acid, and other determinants on Gram positive and negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2. MARCO is required for the organization of the splenic marginal zone and the interaction of local macrophages and B cells.
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SDS-PAGE
SEC-HPLC
The purity of is more than 90% as determined by SEC-HPLC.
RP-HPLC
The purity of is more than 95% as determined by RP-HPLC.
