Measured in a cell proliferation assay using Murine M-NFS-60 cells, the EC50 for this effect is less than 2ng/ml.
M-CSF Protein, Mouse
M-CSF Protein, Mouse
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$144.00 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | M-CSF; CSF-1; Macrophage Colony Stimulating Factor |
| Accession | P07141-1 |
| Amino Acid Sequence | Lys33-Pro187 |
| Expression System | E.coli |
| Molecular Weight | 18.2 kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris，200mM NaCl,pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Cosman D, Wignall J, Anderson D, et al. 1988. Behring Inst Mitt: 15-26. |
Background
Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of several diseases, including breast and endometrial cancers.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized M-CSF Protein, Mouse (Cat. No. UA040128) at 2.0μg/mL (100μL/well) can bind M-CSFR mFc Chimera, Mouse(Cat. No. UA010188) with EC50 of 5.52-8.06 ng/ mL.
