WB result of LRRK2 (phospho S935) Recombinant Rabbit mAb
Primary antibody: LRRK2 (phospho S935) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: GFP-His LRRK2 lysate 5 ug
Lane 2: GFP-His LRRK2 S910A lysate 5 ug
Lane 3: GFP-His LRRK2 S935A lysate 5 ug
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 313 kDa
Observed MW: 280 kDa
LRRK2 (phospho S935) Recombinant Rabbit mAb (S-966-37)
LRRK2 (phospho S935) Recombinant Rabbit mAb (S-966-37)
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$100.00 USD
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$100.00 USD
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | LRRK2 (phospho S935) |
| Synonyms | Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin, PARK8 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q5S007 |
| Clone Number | S-966-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Predicted Reactivity | Ms, Pr, Rt, Pg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 |
Background
LRRK2, also known as Leucine-rich repeat kinase 2, is a large, multi-domain protein kinase that belongs to the ROCO (Ras of complex proteins) family. It is highly conserved across species and plays important roles in various cellular processes, including vesicle trafficking, autophagy, and cytoskeletal dynamics. Mutations in the LRRK2 gene have been linked to several neurodegenerative disorders, most notably Parkinson's disease. The phosphorylation of LRRK2 at S935 has been implicated in modulating its kinase activity and may contribute to the pathogenesis of Parkinson's disease and other LRRK2-related disorders.
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Western Blot
