LOXL2 Recombinant Rabbit mAb (S-4565-21)

LOXL2 (lysyl oxidase-like protein 2) is a multifunctional protein in the lysyl oxidase (LOX) family that possesses both enzymatic activity and signaling regulatory functions. Its structural features include a conserved C-terminal copper-dependent amine oxidase catalytic domain (containing the LTQ cofactor) and four N-terminal scavenger receptor cysteine-rich (SRCR) domains. As a classic matrix-remodeling enzyme, LOXL2 promotes extracellular matrix (ECM) crosslinking by oxidizing lysine residues in collagen and elastin, thereby increasing matrix stiffness and stability, and it plays a central role in tissue fibrosis and tumor microenvironment remodeling. Beyond its enzymatic activity, LOXL2 also has important intracellular functions, promoting tumor invasion and metastasis through non-enzymatic mechanisms such as stabilizing the Snail1 transcription factor, regulating epithelial-mesenchymal transition (EMT), and participating in the regulation of cell polarity. Numerous clinical studies have confirmed that LOXL2 is dysregulated in various malignant tumors and is closely associated with poor prognosis; it is also significantly elevated in liver, lung, and cardiac fibrosis.