IHC shows positive staining in paraffin-embedded human esophagus. Anti-Langerin antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Langerin Recombinant Rabbit mAb (SDT-450-47)
Langerin Recombinant Rabbit mAb (SDT-450-47)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Langerin |
| Synonyms | C-type lectin domain family 4 member K, CD207, CLEC4K |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q9UJ71 |
| Clone Number | SDT-450-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 |
Background
Langerin (CD207) is a type II transmembrane C-type lectin which is encoded by the CD207 gene in humans. Langerin is known to be associated with the formation of Birbeck granules in Langerhans cells (LCs). LCs are immune cells closely related to macrophages, but by their function, they are more like conventional dendritic cells (cDCs). Langerin is a highly selective marker for Langerhans cells and the lesional cells of Langerhans cell histiocytosis.
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Immunohistochemistry
IHC shows positive staining in paraffin-embedded human skin. Anti-Langerin antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Negative control: IHC shows negative staining in paraffin-embedded human cerebral cortex. Anti-Langerin antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
