LAG-3 GST Tag Protein, Human
LAG-3 GST Tag Protein, Human
Product Details
Product Details
Product Specification
| Species | Human |
| Antigen | LAG-3 |
| Synonyms | LAG-3,CD223 Antigen, Protein FDC, CD223, FDC, sLAG-3 |
| Accession | P18627 |
| Amino Acid Sequence | Leu23-Leu450,with N-terminal GST Tag |
| Expression System | HEK293 |
| Molecular Weight | 75-80kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | GST Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Colin G. Graydon, Shifa Mohideen and Keith R.Fowke, LAG3’s Enigmatic Mechanism of Action. Frontiers in Immunology |
Background
LAG3 is a member ofthe immunoglobulin superfamily and a CD4 ancestral homolog, resulting from agene duplication event. Like CD4, LAG3 binds MHC class II (MHCII), but also FGL-1,α-synucleinfibrils (α-syn) and the lectins galectin-3 (Gal-3) and lymph node sinusoidalendothelial cell C-type lectin (LSECtin). As an immune checkpoint, LAG3inhibits the activation of its host cell and generally promotes a moresuppressive immune response. On T cells, LAG3 reduces cytokine and granzymeproduction and proliferation while encouraging differentiation into Tregulatory cells.
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SDS-PAGE
ELISA
Immobilized LAG-3 GST Tag Protein, Human(Cat.No.UA010424) at 2 ug/mL (100 μL/well) can bind Relatlimab (Cat.No. S0B0569), the EC50 is 0.99-1.37ng/mL.
