Kindlin-2 Recombinant Rabbit mAb (S-4572-66)

Kindlin-2, also known as FERMT2 or MIG-2, is a critical cytoplasmic adaptor protein belonging to the Kindlin family that plays an indispensable role in integrin activation, cell adhesion, and mechanotransduction by directly binding to the β-integrin cytoplasmic tail via its C-terminal FERM domain to induce the conformational change necessary for high-affinity ligand binding. Beyond its canonical function in activating integrins at focal adhesions and linking the extracellular matrix to the actin cytoskeleton through interactions with proteins like talin, ILK, and paxillin, Kindlin-2 exhibits unique moonlighting functions by translocating to the nucleus where it interacts with transcription factors such as TCF4 and β-catenin to regulate gene expression involved in cell proliferation, differentiation, and epithelial-mesenchymal transition. Its physiological importance is underscored by the fact that complete loss of Kindlin-2 causes early embryonic lethality due to defective peri-implantation development and impaired basement membrane formation, while its dysregulation is intricately linked to human pathologies including cancer metastasis, cardiac hypertrophy, fibrosis, and muscular dystrophies, making it a pivotal molecule in both developmental biology and disease therapeutics.