IRBP (1-20), Human
IRBP (1-20), Human
Product Details
Product Details
Product Specification
| Species | Human |
| Amino Acid Sequence |
GPTHLFQPSLVLDMAKVLLD
|
| Molecular Weight |
2194.62
|
| Purity | >95% |
| Physical Appearance | Lyophilized Powder |
| Reconstitution |
DMSO : 100 mg/mL (45.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Water : 40 mg/mL (18.23 mM; adjust pH to 8 with NH3·H2O) |
| Stability & Storage | -20℃~ -80℃ |
Background
This peptide is a 1 to 20 amino acid fragment of the interphotoreceptor retinoid binding protein (IRBP). IRBP is a 140-kDa glycolipoprotein residing in the interphotoreceptor matrix between the neural retina and the retinal pigment epithelium. Human IRBP peptide 1-20 contains a major epitope for the H-2b haplotype. Immunization with IRBP (1 – 20) induces T-cell–mediated experimental autoimmune uveoretinitis (EAU) disease. The pathology of disease induced by the peptide, or by adoptive transfer of cells specific to the peptide, is similar to that induced by the whole IRBP protein.
Guidelines
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
