Invivo Anti-Mouse LPAM-1 (Integrin α4β7) Recombinant mAb
Invivo Anti-Mouse LPAM-1 (Integrin α4β7) Recombinant mAb
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | LPAM-1 (Integrin α4β7) |
| Location | Cell membrane |
| Accession | P26011 |
| Clone Number | S-3206 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | FCM, in vivo Integrin α4β7 neutralization |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
LPAM-1 (Lymphocyte Peyer’s patch Adhesion Molecule-1), also designated integrin α4β7, is a 150/130 kDa heterodimeric surface glycoprotein of the integrin immunoglobulin superfamily that is constitutively expressed on naive T and B cells, up-regulated on gut-homing memory CD4⁺ T cells and IgA-secreting plasma cells by retinoic acid, and serves as the principal homing receptor mediating rolling and firm adhesion of these leukocytes to mucosal vascular addressin MAdCAM-1 on high endothelial venules of Peyer’s patches and intestinal lamina propria, thereby orchestrating their trans-endothelial migration into gut-associated lymphoid tissues during both steady-state immune surveillance and inflammatory bowel diseases, and can also engage VCAM-1 and fibronectin to support lymphocyte trafficking and retention.
