Invivo Anti-Mouse CLEC9A (CD370) Recombinant mAb
Invivo Anti-Mouse CLEC9A (CD370) Recombinant mAb
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$120 USD
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CLEC9A (CD370) |
| Synonyms | C-type lectin domain family 9 member A; Dendritic cell natural killer lectin group receptor 1; Dngr-1; Clec9a |
| Location | Membrane |
| Accession | Q8BRU4 |
| Clone Number | S-3283 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG1,k |
| Application | FCM, in vivo CLEC9A blockade |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, pH 7.4, Contains no stabilizers or preservatives |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD370, also known as CLEC9A or DNGR-1, is a type II transmembrane glycoprotein expressed almost exclusively on human CD141⁺ (mouse CD8α⁺) dendritic cells and a minor subset of CD14⁺CD16⁻ monocytes; it functions as an endocytic pattern-recognition receptor that binds exposed filamentous actin on necrotic cell debris, triggering Syk–ITAM signaling that drives efficient cross-presentation of dead-cell antigens to cytotoxic T lymphocytes and thereby links necrosis sensing to initiation of adaptive immunity.
