Flow cytometric analysis of C57BL/6 mouse blood cells labelling CD41 antibody at 1/500 dilution (1 μg) / (Red) compared with a Rat IgG1, κ (Black) Isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (Blue). Goat Anti - Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Gated on total viable cells.
Invivo Anti-Mouse CD41 Recombinant mAb (S-R690)
Invivo Anti-Mouse CD41 Recombinant mAb (S-R690)
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$300.00 USD
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD41 |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; Itga2b |
| Location | Membrane |
| Accession | Q9QUM0 |
| Clone Number | S-R690 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM, Cytotoxicity, Depletion, Induction, Inhibition |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse blood cells |
| Purification | Protein G |
| Concentration | Lot specific* (generally 2 to 10 mg/ml)* |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
CD41, also known as integrin αIIb or platelet glycoprotein IIb, is a crucial protein involved in platelet aggregation and hemostasis. It is encoded by the ITGA2B gene and forms a heterodimer with integrin β3 (CD61) to create the fibrinogen receptor on platelets. This receptor is essential for platelet aggregation, as it binds soluble fibrinogen and other ligands like plasminogen, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Mutations in the CD41 gene can lead to Glanzmann thrombasthenia, a bleeding disorder characterized by prolonged bleeding after injury. CD41 is also used as a marker to identify platelets, megakaryocytes, and hematopoietic progenitor cells.
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