Flow cytometric analysis of BALB/c mouse bone marrow labeled with Anti-Mouse CD31 antibody at 1/500 dilution (1 μg) / (right panel) compared with a Rat IgG2a, κ Isotype Control /(left panel). Goat Anti-Rat IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD45R/B220 - Pacific Blue™ antibody separately. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
Invivo Anti-Mouse CD31 (PECAM-1) Recombinant mAb
Invivo Anti-Mouse CD31 (PECAM-1) Recombinant mAb
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD31 (PECAM-1) |
| Synonyms | Platelet endothelial cell adhesion molecule; PECAM-1; Pecam; Pecam1 |
| Location | Cell membrane |
| Accession | Q08481 |
| Clone Number | S-5620 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a, κ |
| Isotype Control | S0B0932 |
| Application | FCM, in vivo blocking |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
CD31, also known as platelet endothelial cell adhesion molecule (PECAM-1), is a glycoprotein encoded by the PECAM1 gene and expressed on endothelial cells, platelets, and various types of leukocytes. It is a type I transmembrane protein with six extracellular immunoglobulin-like domains, a transmembrane segment, and a short cytoplasmic tail. CD31 plays crucial roles in cell-cell adhesion, immune response, and vascular integrity. It facilitates leukocyte transmigration during inflammation, maintains endothelial cell junctions, and regulates vascular permeability. Additionally, CD31 is involved in angiogenesis and has potential implications in cancer metastasis and thrombus formation. Its expression and function are also implicated in various diseases, including atherosclerosis and Alzheimer's disease.
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