Invivo Anti-Mouse CD205 Recombinant mAb
Invivo Anti-Mouse CD205 Recombinant mAb
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD205 |
| Location | Membrane |
| Accession | Q60767 |
| Clone Number | NLDC-145 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a, κ |
| Isotype Control | S0B0932 |
| Application | FCM, Functional assays |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
CD205, also known as DEC-205, is a type C lectin receptor and a type I membrane glycoprotein belonging to the mannose receptor family. It is highly expressed on dendritic cells (DCs), thymic epithelial cells, and certain epithelial cells. CD205 plays a crucial role in antigen uptake, processing, and presentation, facilitating the induction of antigen-specific T cell immunity. This receptor is involved in endocytosis, capturing antigens from the extracellular space and transporting them to specialized compartments for processing. Its high efficiency in antigen presentation makes it a valuable target in immunotherapy, particularly for developing vaccines against viruses and tumors. Additionally, CD205 has been found to recognize apoptotic and necrotic cells in an acidic environment through its interaction with keratin.
