IL-7 R alpha&TSLP R Heterodimer Fc Tag&Fc Tag Protein, Human
IL-7 R alpha&TSLP R Heterodimer Fc Tag&Fc Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | IL7Ra, CD127, TSLP R, CRLF2, IL-XR, ILXR, p2RY8, CRLF2 fusion, TSLP receptor, TSLPR, CRL2, CRLF2Y, Cytokine receptor-like 2 |
| Accession | P16871-1、Q9HC73-1 |
| Amino Acid Sequence | IL-7 RA: Glu 21 - Asp 239 (IL-7 RA), with a human IgG1 Fc fragment at the C-terminus |
| Expression System | HEK293 |
| Molecular Weight | 51.7 kDa (IL-7 RA) and 50.3 kDa (TSLP R), The reducing (R) protein migrates as 60-80 kDa due to glycosylation |
| Purity | > 95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 with trehalose as protectant. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
TSLP is a pleiotropic cytokine originally characterized as a lymphocyte growth factor. Thymic stromal lymphopoietin (TSLP) is overexpressed in the airways of severe asthmatics and is an upstream cytokine that orchestrates inflammatory responses in asthma. Human TSLP exerts its biological activities by binding to a high-affinity heteromeric receptor complex composed of TSLPR and IL- 7 receptor and initiates signaling in cells co-expressing TSLPR and IL-7R.
