Immobilized Cynomolgus IL-6 Protein, His Tag at 5 μg/mL (100 μL/well) can bind Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human (UA011222) with EC50 of 17.13-29.83 ng/ml.
IL-6 His Tag Protein, Cynomolgus
IL-6 His Tag Protein, Cynomolgus
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Product Details
Product Details
Product Specification
| Species | Cynomolgus |
| Synonyms | Interleukin-6, IL6 |
| Accession | P79341 |
| Amino Acid Sequence | Protein sequence (P79341, Ala28-Met212, with C-His Tag) APVLPGEDSKDVAAPHSQPLTSSERIDKHIRYILDGISALRKETCNRSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEDTCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPEPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 22.7 kDaObserved MW: 24-30 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10. IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as multiple sclerosis, diabetes, atherosclerosis, depression, Alzheimer's disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, rheumatoid arthritis, and intracerebral hemorrhage.
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Bioactivity
SDS-PAGE
2μg（R: reducing conditions）
