IL-4 Recombinant Rabbit mAb (SDT-505-75)
IL-4 Recombinant Rabbit mAb (SDT-505-75)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-4 |
| Immunogen | Recombinant Protein |
| Accession | P05112 |
| Clone Number | SDT-505-75 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize IL-3, IL-5, IL-13, GM-CSF |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A | |
| CLIA | N/A |
Background
IL-4 is a cytokine that functions as a potent regulator of immunity secreted primarily by mast cells, Th2 cells, eosinophils and basophils. IL-4 initiates signal transduction through one of two different receptor complexes, a type I receptor expressed on hematopoietic cells or a type II receptor expressed on nonhematopoietic cells. The type I receptor consists of the IL-4 R alpha and common gamma-chain/IL-2 R gamma subunits and is specific for IL-4, while the type II receptor consists of the IL-4 R alpha and IL-13 R alpha 1 subunits and can be activated by either IL-4 or IL-13. In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated.
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