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IL-31 His Tag Protein, Human

IL-31 His Tag Protein, Human

Catalog Number: UA100049 Brand: UA BIOSCIENCE
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$170 USD
$170 USD
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Product Details

Product Specification


Species Human
Accession Q6EBC2
Amino Acid Sequence

Ser24-Thr164, with N-His Tag
Expression System HEK293
Molecular Weight

Predicted MW: 17.5 kDa Observed MW: 20 kDa
Purity >95% by SDS-PAGE
Endotoxin <1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

0.2M PBS, pH7.4 with 3% trehalose.
Reconstitution

Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage


12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Interleukin-31 (IL-31) is a novel cytokine belonging to the IL-6 family, primarily produced by activated T helper 2 (Th2) cells and mast cells. It signals through a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor β (OSMRβ), which is expressed on various cell types including sensory neurons, keratinocytes, and immune cells. IL-31 is a key mediator of pruritus (itch) in inflammatory skin diseases such as atopic dermatitis, psoriasis, and allergic conditions. Its signaling pathway promotes itch sensation, disrupts epidermal barrier function, and drives immune responses, making it a significant therapeutic target for chronic pruritic disorders.

Picture

SDS-PAGE

2μg（R: reducing conditions）

ELISA

Immobilized Human IL-31 Protein, His Tag at 1 μg/mL (100 μL/well) can bind Human IL-31 RA Protein, Fc Tag with EC50 of 0.11-0.15 μg/ ml.