IL-3β Protein, Rat

Catalog Number: UA040225 Brand: UA BIOSCIENCE

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$180 USD

Size: 10μg 50μg 100μg 500μg 1mg

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Product Details

Product Specification

Species	Rat
Synonyms	Hematopoietic Growth Factor; MCGF; Multipotential Colony-stimulating Factor; P-cell-stimulating Factor
Accession	P97688
Amino Acid Sequence	Met26-Cys169
Expression System	E.coli
Molecular Weight	16kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653. Mangi, M.H. and A.C. Newland (1999) Cytokines Cell. Mol. Ther. 5:87. Esandi, M. del C. et al. (1998) Gene 211:151. Cohen, D.R. et al. (1986) Nucleic Acids Res. 14:3641. Gebicke-Haerter, P.J. et al. (1994) J. Neuroimmunol. 50:203.

Background

Interleukin-3 (IL-3) is a type of biological signal (cytokine) which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. It exerts its biological activities through binding to Interleukin-3 receptors included α and β subunits, but sequence analysis revealed a number of features indicative of the presence of only one β-subunit in the rat. Interleukin-3 acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Furthermore, rat and human IL-3 share low homology and have not cross species activity.