IL-28B/IFNL3 Protein, Mouse

Catalog Number: UA040199 Brand: UA BIOSCIENCE

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$256 USD

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Product Details

Product Specification

Species	Mouse
Synonyms	IL-21B,IFNL3
Accession	Q8CGK6
Amino Acid Sequence	Asp20-Val193
Expression System	E.coli
Molecular Weight	20kDa (Reducing)
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Sci Rep. 2020 Dec 1;10(1):20973. 2. Int Immunopharmacol. 2022 Aug:109:108799. Epub 2022 May 4.

Background

IL-28 is a family of cytokines that belongs to interferons termed as λ-interferons or type III interferons (IFN). This family includes IL-28A(IFN-λ2), IL-28B(IFN-λ3) and IL-29(IFN-λ1) in human and IL-28A and IL-28B in mice. IL-28A, IL-28B and IL-29 share a unique heterodimeric receptor IFNLR consisting of IL-28Rα and IL-10R, which is mainly expressed by epithelial cells, dendritic cells (DCs) and macrophages. IL-28B inhibits M2 macrophage polarization in vitro, while also halting M2 macrophage differentiation predominantly via inhibition of the signal transducer and activator of transcription (STAT)3 and c-Jun N-terminal kinase (JNK) signaling pathways. Results reveal a protective role of IL-28B via regulation of epithelial cells in protease induced asthma.