IL-28 Recombinant Rabbit mAb (SDT-1616-14-2)
IL-28 Recombinant Rabbit mAb (SDT-1616-14-2)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-28 |
| Synonyms | IL-28A/IFN-λ2, IL-28B/IFN-λ3 |
| Immunogen | Recombinant Protein |
| Location | N/A |
| Accession | Q8IZI9、Q8IZJ0 |
| Clone Number | SDT-1616-14-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against human IL-29, recognize both IL-28A and IL-28B. |
| Purification | Protein A |
| Concentration | 2mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are. IL-28 has also been shown to play a role in the adaptive immune response.
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