Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-25 |
| Synonyms | IL-17E |
| Immunogen | Recombinant Protein |
| Accession | Q9H293 |
| Clone Number | SDT-615-98 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Does not recognize IL-17A, IL-17F |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A |
Background
L-17E/IL-25 (Interleukin-25) is a cytokine that belongs to the IL-17 cytokine family. Binding of IL-25 occurs via a heterodimer complex composed of IL-17RB and IL-17RA. The production of IL-25 by injured epithelial cells is an important innate immune signal driving Th2 immune deviation in the subsequent adaptive immune response. IL-25 is an important mediator of allergic reactions and protection against intestinal parasites. IL-25 stimulates release of IL-4, IL-5, and IL-13 from Th2 lymphocytes but, of note, also drives IL-5 and IL-13 secretion from type 2 innate lymphoid cells (ILC2)
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