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IL-23A(20-189) Fc Chimera Protein, Human

IL-23A(20-189) Fc Chimera Protein, Human

Catalog Number: UA011357 Brand: UA BIOSCIENCE
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$210 USD
$210 USD
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Product Details

Product Specification


Species Human
Synonyms IL23A, IL-23, IL-23A, IL23P19, P19, SGRF
Accession Q9NPF7
Amino Acid Sequence

Arg 20 - Pro 189 with hIgG1 Fc Tag at the C-Terminus
Expression System HEK293
Molecular Weight 43-55kDa (Reducing)
Purity ＞95% by SDS-PAGE &
Conjugation Unconjugated
Tag Human IgG1 Fc
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oppmann, B., et al. (2000). Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity, 13(5), 715-725.
2. McGovern, D., Powrie, F. (2007). The IL-23 axis plays a key role in the pathogenesis of IBD. Gut, 56(10), 1333-1336.
3. Di Cesare, A., Di Meglio, P., Nestle, F. O. (2009). The IL-23/Th17 axis in the immunopathogenesis of psoriasis. Journal of Investigative Dermatology, 129(6), 1339-1350.

Background

Interleukin-23A (IL-23A) is a key pro-inflammatory cytokine that belongs to the IL-12 cytokine family. It forms a heterodimeric complex with IL-12B (p40 subunit) to create the bioactive IL-23 cytokine (composed of p19 and p40 subunits). IL-23 is primarily produced by activated dendritic cells, macrophages, and monocytes. Its biological function is mediated through binding to a specific receptor complex, IL-23R, which pairs with IL-12Rβ1, expressed mainly on the surface of immune cells such as T helper 17 (Th17) cells, innate lymphoid cells, and macrophages.

The primary role of IL-23 is to stabilize and expand the Th17 cell lineage, which subsequently produces effector cytokines like IL-17A, IL-17F, and IL-22. This IL-23/Th17 axis is a central driver of chronic inflammation and autoimmune pathology. Consequently, dysregulated IL-23 signaling is strongly implicated in the pathogenesis of several immune-mediated inflammatory diseases, including psoriasis, psoriatic arthritis, inflammatory bowel disease (e.g., Crohn's disease), and ankylosing spondylitis. This critical involvement has made IL-23A and its receptor prime therapeutic targets, with several monoclonal antibodies achieving significant clinical success.

Picture

SDS-PAGE

2μg (R: reducing condition, N: non-reducing condition).

ELISA

Immobilized IL-23A(20-189) Fc Chimera Protein, Human (Cat. No. UA011357) at 1.0μg/mL (100μL/well) can bind Biotinylated Guselkumab (Cat. No. S0B0563) with EC50 of 10.77-14.25 ug/mL.