2μg (R: reducing condition, N:non-reducing condition).
IL-23 R Fc Chimera Protein, Human
IL-23 R Fc Chimera Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | IBD17,IL-23 receptor |
| Accession | Q5VWK5-1 |
| Amino Acid Sequence | Gly24-Gly355 with hIgG1 Fc at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-110kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | Human IgG1 Fc |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Benson JM, Sachs CW, Treacy G, Zhou H, Pendley CE, Brodmerkel CM, Shankar G, Mascelli MA. Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab. Nat Biotechnol. 2011 Jul;29(7):615-24. |
Background
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of p19 and p40 subunits. Its functional receptor, IL-23R, combines with the IL-12Rβ1 subunit to form a type I cytokine receptor complex. This complex activates the downstream JAK2-STAT3 signaling pathway, regulating the proliferation, differentiation, and secretion of inflammatory factors in immune cells such as T cells and NK cells. It plays a central role in sustaining Th17 cell-mediated inflammatory responses. Clinically, abnormal activation of the IL-23/IL-23R pathway is a key pathogenic mechanism in autoimmune diseases such as psoriasis and inflammatory bowel disease. Additionally, it promotes tumorigenesis within the tumor microenvironment, making it a critical therapeutic target.
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SDS-PAGE
SEC-HPLC
The purity of IL-23 R Fc Chimera Protein, Human is more than 95% determined by SEC-HPLC.
ELISA
Immobilized Human IL-23 alpha & IL-12 beta Heterodimer Protein, No tag&His tag (Cat. No. S0A4041) at 1.0μg/mL (100μL/well) can bind IL-23 R Fc Chimera Protein, Human (Cat. No. UA016005) with EC50 of 20.7-29.4ng/mL.
SPR
IL-23 R Fc Chimera Protein, Human (Cat. No. UA016005) captured on Protein A Chip can bind Human IL-23 alpha & IL-12 beta Heterodimer Protein, No tag&His tag(Cat. No. S0A4041) with an affinity constant of 17.56 nM as determined in a SPR assay .
