Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The ED50 for this effect is less than 60ng/mL.
IL-21 Protein, Mouse
IL-21 Protein, Mouse
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$160.00 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | IL-21, rMuIL-21, Za11 |
| Accession | Q9ES17 |
| Amino Acid Sequence | Pro25-Ser146 |
| Expression System | E.coli |
| Molecular Weight | 14kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 100mM NaCl, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Coquet J M. et al. (2007) IL-21 is produced by NKT cells and modulates NKT cell activation and cytokine production. J Immunol. 178(5):2827-34. 2、Wei L. et al. (2007) IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem. 282(48):34605-10. 3、Parrish-Novak J. et al. (2002) Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J Leukoc Biol. 72(5):856-63. 4、Kuchen S. et al. (2007) Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol. 179(9): 5886-96. |
Background
IL-21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. IL-21 is a T-cell–derived cytokine that works in concert with other γc cytokines. It synergizes with IL-7 and IL-15 to expand and activate CD8 T cells. IL-21 also augments the activity of NK cells. IL-21, along with IL-6, drives differentiation of Tfh. Tfh cells are found preferentially in B-cell follicles, where, under the control of the transcription factor BCL6, they regulate B-cell development, activation, and class switching. Tfh cells are also a source of IL-21. IL-21 appears to have some anticancer properties, and it has been tested in the treatment of melanoma.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
