Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The EC50 this effect is less than 0.2ng/ml.
IL-2 Protein, Mouse
IL-2 Protein, Mouse
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$106.00 USD
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-2蛋白；IL-2蛋白;aldesleukin; interleukin 2; interleukin-2; IL-2; IL2; T-cell growth facter; T cell growth factor; TCGF ; REF: C1025 |
| Accession | P04351 |
| Amino Acid Sequence | Ala21-Gln169 |
| Expression System | E.coli |
| Molecular Weight | 18 kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Sodium Citrate, pH3.0. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657. 2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109. 3. Kashima, N. et al. (1985) Nature 313:402. 4. Matesanz, F. et al. (1993) Immunogenetics 38:300. 5. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813. 6. Liparoto, S.F. et al. (2002) Biochemistry 41:2543. 7. Wang, X. et al. (2005) Science 310:1159. 8. Bodnar, A. et al. (2008) Immunol. Lett. 116:117. 9. Jaleco, S. et al. (2003) J. Immunol. 171:61. 10. Malek, T.R. (2003) J. Leukoc. Biol. 74:961. 11. Laurence, A. et al. (2007) Immunity 26:371. 12. Kryczek, I. et al. (2007) J. Immunol. 178:6730. 13. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32. 14. Fehervari, Z. et al. (2006) Trends Immunol. 27:109. |
Background
Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL2 shares 56% and 73% aa sequence identity with human and rat IL2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity.
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Bioactivity
SDS-PAGE
1μg (R: reducing condition, N: non-reducing condition).
RP-HPLC
Purity > 98.9% determined by RP-HPLC
ELISA
Immobilized IL-2 Protein, Mouse (Cat. No. UA040171) at 2μg/mL (100μL/well) can bind Mouse Soluble IL2R alpha/CD25 Protein, His tag with EC50 of 7.9-15.5 ng/mL.
