IL-19 Recombinant Rabbit mAb (SDT-355-231)
IL-19 Recombinant Rabbit mAb (SDT-355-231)
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | IL-19 |
| Synonyms | Interleukin-19; IL-19; Melanoma differentiation-associated protein-like protein; NG.1; ZMDA1; IL19 |
| Immunogen | Recombinant Protein |
| Location | Secreted |
| Accession | Q9UHD0 |
| Clone Number | SDT-355-231 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against il-10, il-20, il-22 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
Interleukin-19 (IL-19) is an immunosuppressive cytokine belonging to the IL-10 subfamily, encoded by the IL-19 gene located on chromosome 1. It is preferentially expressed in monocytes, macrophages, and T and B lymphocytes. IL-19 binds to the IL-20 receptor complex, activating the JAK-STAT signaling pathway, which promotes the Th2 (regulatory) T-cell response, supports an anti-inflammatory lymphocyte phenotype, and inhibits the production of pro-inflammatory cytokines like IFN-γ. It also suppresses the expression of RNA-binding protein HuR, reducing the translation of cell adhesion molecules and limiting vascular tissue damage. However, IL-19 has also been reported to enhance chronic inflammatory diseases, as it regulates cells of the monocyte lineage and affects processes like cell differentiation.
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